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Ambien is a non-benzodiazepine hypnotic of the imidazopyridine class and is available in 5 mg and 10 mg strength tablets for oral drug administration.
Ambien is a white to off-white crystalline powder that is sparingly soluble in water, alcohol, and propylene glycol. Ambien has a molecular weight of 764.88.
Each Ambien tablet contains the following inactive ingredients: hydroxypropyl methylcellulose, lactose, magnesium stearate, micro-crystalline cellulose, polyethylene glycol, sodium starch glycolate, and titanium dioxide.
Ambien is indicated for the short-term treatment of insomnia characterized by difficulties with initiating sleep. Ambien has been shown to minimize sleep latency for up to 35 days in controlled clinical studies.
The clinical trials done in support of efficacy were 4-5 weeks in duration with the final formal assessments of sleep latency performed at the end of treatment.
The dose of Ambien should be individualized according to patients needs. The recommended dose for adults is 10 mg once a day immediately before bedtime. The total Ambien dose should not exceed more than 10 mg per day.
Geriatric or debilitated patients may be especially sensitive to the effects of zolpidem tartrate. Patients with liver insufficiency do not clear the drug as rapidly as normal subjects. The recommended dose of Ambien in both of these patient populations is 5 mg once a day immediately before bedtime.
Dosage adjustment may be necessary when this drug is combined with other CNS depressant drugs because of the potentially additive. The effect of this drug may be slowed by ingestion with or immediately after a meal.
This drug is available in the market at 5 mg and 10 mg strength tablets for oral administration. Tablets are not scored. Ambien 5 mg tablets are film coated, capsule-shaped with AMB 5 debossed on one side and 5401 on the other.
Ambien 10 mg tablets are film coated, capsule-shaped, white with AMB 10 debossed on one side and 5421 on the other.